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Intracranially implanted SLC7A11 expressing tumor cells grow faster, produce more glutamate toxicity, induce seizures, and shorten overall survival (107)

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Single myocyte studies have also shown that cell-wide m depolarization, through a reactive oxygen species (ROS) -induced ROS release mechanism, can be triggered by global depletion of the antioxidant pool with diamide, a glutathione oxidant